' 
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 4 Capsules
Serving Per Container: 30
Amount Per Serving
%DV
Vitamin C (from culture of S. cerevisiae)
50 mg
56%
Vitamin D (as D3 from culture of S. cerevisiae)
40 mcg (1,600 IU)
200%
Vitamin K (from culture of S. cerevisiae)
120 mcg
100%
Calcium (naturally occurring from Algae)
1,100 mg
85%
Magnesium (from Algae and Dead Sea minerals)
357 mg
85%
Vitamin K (as K2 MK-7)
50 mcg
+
Strontium (naturally occurring from Algae)
3.8 mg
+
Boron (from Brown Rice Chelate)
3 mg
+
Silica (naturally occurring from Algae)
2.2 mg
+
Vanadium (naturally occurring from Algae)
25 mcg
+
Raw Probiotic & Enzyme BlendLipase, Protease, Aspergillopepsin, beta-Glucanase, Cellulase, Bromelain, Phytase, Lactase, Papain, Peptidase, Pectinase, Hemicellulase, Xylanase, [Lactobacillus bulgaricus, Lactobacillus plantarum] (500 Million CFU).
64 mg
+
Top Medical Research Studies
8
Magnesium's impact on heart health
The Role of Dietary Magnesium in Cardiovascular Disease.
Direct relationship to heart disease
We examined the connection between dietary magnesium and cardiovascular disease, focusing on how magnesium intake or serum levels relate to heart health. Over the last couple of decades, numerous studies have shown that low magnesium levels are associated with several heart-related issues, including high blood pressure, heart attacks, and even heart failure.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
Our insights reveal that even mild or moderate magnesium deficiencies can trigger physiological and metabolic changes that may heighten cardiovascular risks. When magnesium levels are insufficient, we see a rise in inflammation, oxidative stress, and issues with how fats are processed in the body, which can lead to serious heart problems.
Furthermore, we noted that many individuals often consume less magnesium than what is recommended, particularly those who do not regularly eat whole grains, legumes, or green vegetables. This widespread lack of magnesium is concerning, as it could be a significant factor influencing heart disease in the general population.
Read More
9
Vitamin D reduces foam cell formation
Vitamin D reduces VSMC foam cell formation and protects against AS progression.
Highly relevant to cardiovascular management
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Read More
9
Magnesium may help arterial health
Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium.
Highly relevant to cardiovascular disease.
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
Most Useful Reviews
8.8
Supports bone health
Excellent! I’ve been taking “Garden of Life Vitamin Code Raw Calcium”, as recommended by my doctor, for two years now. I take two pills each evening with 200mg of magnesium. This combination significantly improves my sleep quality and alleviates heavy muscle pain, making me feel lighter in the morning. I found it particularly beneficial for bone health and cardiovascular disease.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7
- All Researches
9
Vitamin D reduces foam cell formation
Vitamin D reduces VSMC foam cell formation and protects against AS progression.
Highly relevant to cardiovascular management
We set out to explore how vitamin D impacts the formation of foam cells from vascular smooth muscle cells (VSMCs), which are key players in the development of atherosclerosis. Our investigation centered on whether vitamin D could suppress the creation of these foam cells and the potential involvement of a receptor called Toll-like receptor 4 (TLR4) in this process.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Using ApoE-/- mice, we assessed the effects of vitamin D supplementation on atherosclerotic plaque formation and looked at the expression of important genes related to cholesterol transport and TLR4. The results were promising—supplemental vitamin D significantly reduced the formation of foam cells and atherosclerotic plaques in the aorta. We noticed that vitamin D not only decreased the expression of TLR4 and other foam cell markers but also encouraged the upregulation of cholesterol transport proteins that help maintain healthy cell function.
In laboratory conditions, vitamin D proved effective in reducing the uptake of oxidized LDL by VSMCs while enhancing the efflux of cholesterol. Notably, we discovered that knocking down TLR4 impaired foam cell formation, suggesting its critical role in this process.
Overall, our findings highlight that vitamin D might be a protective agent against cardiovascular disease by reducing foam cell formation through the JNK-TLR4 signaling pathway. This suggests a potential avenue for dealing with atherosclerotic disease through vitamin D treatment.
Read More
9
Impact of renal function on anticoagulation
Renal function and adverse clinical events in anticoagulated patients with atrial fibrillation: insights from the GLORIA-AF Registry Phase III.
High relevance for clinical practice
We explored how kidney function impacts the safety and effectiveness of different anticoagulant therapies in patients with atrial fibrillation. By analyzing data from the GLORIA-AF registry involving over 10,000 patients, we found that better kidney function was linked to lower risks of serious health events.
Notably, those on non-vitamin K antagonist oral anticoagulants (NOACs) experienced significantly improved outcomes compared to those using vitamin K antagonists (VKAs). This suggests that NOACs are a safer choice for AF patients, especially for those with varying levels of kidney function.
Notably, those on non-vitamin K antagonist oral anticoagulants (NOACs) experienced significantly improved outcomes compared to those using vitamin K antagonists (VKAs). This suggests that NOACs are a safer choice for AF patients, especially for those with varying levels of kidney function.
Read More
9
Magnesium may help arterial health
Mitigation of arteriosclerosis through transcriptional regulation of ferroptosis and lipid metabolism by magnesium.
Highly relevant to cardiovascular disease.
We investigated how magnesium impacts cardiovascular health, particularly its role in a condition known as arteriosclerosis. This disease can lead to serious heart complications, but recent studies revealed magnesium's potential benefits.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
In a series of experiments involving human cells and animal models, we discovered that magnesium effectively reduces a process called ferroptosis, which is linked to the progression of arteriosclerosis. It appears that magnesium ions play a vital role by preventing certain proteins from breaking down. This action promotes the expression of protective proteins while reducing harmful components that contribute to the disease.
Notably, our animal tests highlighted that biodegradable magnesium stents not only hinder ferroptosis but also slow down the advancement of arteriosclerosis. This suggests that magnesium-based treatments could offer a promising avenue for combating cardiovascular diseases effectively.
Read More
8
Vitamin D3's role in cardiovascular health
Unveiling the benefits of Vitamin D3 with SGLT-2 inhibitors for hypertensive obese obstructive sleep apnea patients.
Explores vitamin D3's effects
Our study delved into the potential benefits of vitamin D3 in improving cardiovascular health, particularly among hypertensive patients suffering from obesity and obstructive sleep apnea (OSA). We designed a randomized clinical trial where participants received either dapagliflozin (an SGLT-2 inhibitor), vitamin D3, a combination of both, or no treatment over a period of 16 weeks.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
We evaluated various health parameters including weight, blood pressure, blood sugar levels, and heart function, and analyzed their impact on participants' quality of life. Interestingly, our results indicated that when vitamin D3 was combined with SGLT2 inhibitors, there were notable improvements in several cardio-metabolic outcomes and quality of life measures.
This finding suggests that the dual approach could be a promising strategy in managing cardiovascular risks associated with obesity and OSA. Though our study does not isolate the effects of vitamin D3 alone on cardiovascular disease, it highlights its potential role when paired with other treatments, offering a glimmer of hope for patients dealing with these health challenges.
Read More
8
Vitamin D benefits blood pressure management
Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis.
Relevant to cardiovascular health
We examined the role of vitamin D supplementation in managing hypertension, particularly its effects on cardiovascular health. After analyzing data from a systematic review and meta-analysis that included 24 relevant studies, we discovered that vitamin D has significant benefits for blood pressure.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
The findings revealed that vitamin D supplementation was linked to a notable reduction in both systolic and diastolic blood pressure. Specifically, vitamin D led to a decrease in systolic blood pressure by an average of 2.83 mmHg and diastolic blood pressure by 1.64 mmHg. This is promising news for those looking to manage hypertension more effectively.
Unlike calcium and magnesium, which only significantly lowered diastolic blood pressure but didn't impact systolic blood pressure or pulse rate, vitamin D showed consistent and significantly positive outcomes. Therefore, incorporating vitamin D into treatment plans for hypertensive patients could be a beneficial step toward improving cardiovascular health.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Supports bone health
Excellent! I’ve been taking “Garden of Life Vitamin Code Raw Calcium”, as recommended by my doctor, for two years now. I take two pills each evening with 200mg of magnesium. This combination significantly improves my sleep quality and alleviates heavy muscle pain, making me feel lighter in the morning. I found it particularly beneficial for bone health and cardiovascular disease.
Read More
